Dolo Meta B Composition, Use, Dose, Side Effect

Dolo meta-B is a drug for treating nerve and body pain. It is a combination of vitamins and a nonsteroidal antiinflammatory agent. It is manufactured by Jiangsu Ruinian Qianjin Pharmaceutical Co., Ltd. China.

Dolo meta B

Composition Of Dolo Meta B

Each film coated tablet contains:

Vitamin B12 50 mg

Vitamin B6 100 mg

Vitamin B12 100 ug

Diclofenac sodium 50 mg

Clinical Pharmacology

The action of Dolo-Meta B can be attributed to its components. Diclofenac sodium is a non-steroidal anti-inflammatory agent (NSAID) that possesses analgesic and antipyretic activities. Its mode of action, like that of other NSAIDs, is not known.

However, its therapeutic action is not due to pituitary-adrenal stimulation, but may be from the inhibitory action in the synthesis of prostaglandin. It exhibits very marked anti-rheumatic, anti-inflammatory, analgesic and antipyretic properties and is thus suitable for use in inflammatory and degenerative rheumatic disease as well as for the treatment of post-traumatic inflammation and swelling.

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In patients treated for rheumatoid arthritis and osteoarthritis, the anti-inflammatory action has been shown by reduction in joint swelling, reduction in pain, and also reduction in duration of morning stiffness.

Thiamine (Vit B1), Vit B12, Pyridoxine (Vit B6) are used in treating neurological symptoms such as peripheral neuritis. Vitamin B1 (Thiamine) is a water-soluble vitamin. It is an essential enzyme for carbohydrate metabolism.

Severe Thiamine deficiency is characterized by lactic acidosis and neurological deterioration such as peripheral neuropathy, muscle wasting and muscle weakness.

Vitamin B6 (Pyridoxine) is also a water-soluble vitamin which is involved principally in amino-acid metabolism, but is also involved in carbohydrate and fat metabolism. Its deficiency may lead to sideroblastic anemia, dermatitis, cheilosis and neurological symptoms such as peripheral neuritis and convulsions.

Vitamin B12 (Cyanocobalamin) is a water-soluble vitamin, occurs in the body mainly as methyl cobalamin (mecobalamin) and as adenosyl cobalamin (cobamamide). These act as coenzymes in nucleic acid synthesis. Deficiency is more likely in patients with malabsorption syndromes or metabolic disorders.

Its deficiency leads to the development of megaloblastic anemia and demyelination and other neurological damage. These vitamins, when used individually or in combination, have a remarkable effect on the regeneration of nerves.

Indication Of Dolo Meta B

Musculoskeletal and joint disorder, inflammation, pain, neuralgia and neuritis (Neuropathies).

Contra-indication

- Dolo-Meta B is contra-indicated in patients with hypersensitivity to any of its components.

- Avoid use in the presence of peptic ulcer, pregnancy, lactation hypersensitivity (e.g., asthma attacks) to acetylsalicylic acid or other NSAID agent, severe disorders of liver function in hematopoietic disorders.

Interaction

- Diclofenac Sodium as an active ingredient, avoid concomitant administration with other NSAID.

- Anticoagulants, probenecid, diuretic, Beta-blocker, Corticosteroids, Oral anti-diabetics, cyclosporine, digoxin.

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Precautions

It should be used with caution in patients with evidence of peptic ulcer, those with unexplained gastrointestinal disorders, those with liver or kidney damage and those with high blood pressure, elderly.

Adverse Effects Of Dolo Meta B

Gastrointestinal upsets upper abdominal pain, nausea, diarrhea, light headedness of headaches at the start of treatment. These effects are generally mild and usually regress after a few days. Hypersensitivity reactions such as skin rash and pruritus, asthma attacks and a tendency to oedema may arise.

Dosage And Administration Of Dolo Meta B

Adult: One tablet daily or as directed by a physician.