Ferobin-plus Capsule Composition, Use, Dose, Side Effect

Ferobin-plus capsule is a sister to astyfer capsule. It is made by godson healthcare Plc, Nigeria. It contains less ingredients than astyfer but the same iron salt.

Ferobin-plus capsule

Composition Of Ferobin Plus Capsule

Each capsule contains: ferrous fumarate BP 300mg, vitamin B12 BP 10 mcg and folic acid BP 5 mg.

Description

Ferobin-plus capsule contains ferrous fumarate as a source of iron for the treatment of iron deficiency anemia. It also contains folic acid and cyanocobalamin (vitamin B12) which are used in treatment of megaloblastic anemia.

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Clinical Pharmacology

Iron is an integral component of the body being necessary for hemoglobin formation. Hemoglobin is essential in oxygen transport and the oxidative processes of living tissues. Iron deficiency results in defective erythropoiesis and anemia. Iron deficiency anemia responds to oral iron therapy.

Indication And Use Of Ferobin Plus Capsule

Ferobin-plus capsule is indicated for:

-Nutritional supplement

-iron-deficiency anemia

-Megaloblastic anemia

-Anemia dua to pregnancy

-Anama due to excessive or repeated hemorrhage

-Anemia associated with infections and malignant diseases

Side Effects Of Ferobin Plus Capsule

Nausea, diarrhea or constipation, abdominal discomfort or pain, gastrointestinal upset and black stool.

Precaution

Caution should be examined in patients with a history of peptic ulcer, severe kidney failure and any allergy to any of the constituents.

Contraindications

Hypersensitivity to any of the ingredient

Drug Interaction

Iron forms an insoluble complex with several other drugs, resulting in decreased absorption of both iron and other drugs. Examples include tetracycline, penicillamine, methyldopa, levodopa, biphosphate and quinolones. The same can occur with elements in foods such as calcium.

Absorption of iron is better at low pH (an acid environment) and resorption is decreased if there is a simultaneous intake of antacid, phosphate, etc.

Dosage Of Ferobin Plus Capsule

Adult and Children above 12 years:

As nutritional supplement 1 capsule daily

During illness, blood loss, general weakness or pregnancy: 1 capsule twice daily

Symptoms Of Overdose And Antidote

The absorption of excessive quantities of ingested iron results in systemic iron toxicity. Severe overdose causes impaired oxidative phosphorylation and mitochondrial dysfunction, which can result in cellular death.

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The liver is one of the organs most affected by iron toxicity but other organs such as the heart, kidneys, lungs and hematologic systems may also be impaired. Individuals demonstrate signs of GI toxicity with injections of more than 20 mg/kg, but less than or equal to 40 mg/kg.

Acute overdose can be fatal to children and adults and can occur by both oral and parenteral routes. Methods for preventing toxicity utilize gastric lavage and chelating agents.