General Properties Of Pharmaceutical Tablet

Tablet is defined as a compressed solid dosage form containing medicaments with or without excipients. They vary in shape and differ greatly in size and weight, depending on amount of medicinals instances and the intended mode of administration. It is the most popular dosage form and 70% of the total medicines are dispensed in the form of tablets.

Pharmaceutical tablet

Tablets are prepared either by molding or by compression. The excipients can include diluents, binders or granulating agents, glidants (flow aids) and lubricants to ensure efficient tabletting; disintegrants to promote tablet break-up in the digestive tract; sweeteners or flavours to enhance taste; and pigments to make the tablets visually attractive or aid in visual identification of an unknown tablet.

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A polymer coating is often applied to make the tablet smoother and easier to swallow, to control the release rate of the active ingredient, to make it more resistant to the environment (extending its shelf life), or to enhance the tablet's appearance. Medicinal tablets were originally made in the shape of a disk of whatever color their components determined, but are now made in many shapes and colors to help distinguish different medicines. Tablets are often stamped with symbols, letters, and numbers, which enable them to be identified. Sizes of tablets to be swallowed range from a few millimetres to about a centimetre.

Properties Of Tablet

Drug-like properties, such as solubility, permeability, metabolic stability and transporter effects are of critical importance for the success of drug candidates. They affect oral bioavailability, metabolism, clearance, toxicity, as well as in vitro pharmacology. A pharmaceutical tablet must meet these criteria to be accepted;

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1. Accurate dosage of medication, uniform in weight, appearance and diameter

2. Have the strength to withstand the rigors of mechanical shocks encountered in its production, packaging, shipping and dispensing

3. Release the medicinal agents in the body in a predictable and reproducible manner

4. Elegant product, acceptable size and shape

5. Chemical and physical stabilities