Testyfer Syrup Composition, Dose, Use, Side Effect

Testyfer syrup is a blood tonic. It is similar to astyfer tonic because it contains similar ingredients with similar strength. Astyfer tonic is the few bloods tonic in Nigeria with ferrous glycine with Testyfer tonic joining the bandwagon. Testyfer tonic is manufactured by Gopaldas Visram and Company Limited, India. and marketed by Suitelife Pharmaceutical Ltd. in Nigeria.

Testyfer syrup 

Composition Of Testyfer Syrup

Each 10 ml Contains:

Ferrous Glycine Sulphate (Equivalent to Elemental Iron 47mg) 275 mg

L-Lysine HCL USP 25 mg

Thiamine Hydrochloride BP 5 mg

Nicotinamide BP 25 mg

Cyanocobalamin BP 2.5 mcg

Dexpanthenol USP 2.5 mg

L-Histidine HCL H2O BP 4 mg

Riboflavin BP 3 mg (As Riboflavin Sodium Phosphate)

Pyridoxine Hydrochloride BP 1.5 mg

Folic Acid BP 0.5 mg

Colour Caramel USP/NF

Flavoured Syrupy Base q.s.

Overages of vitamins added to compensate for loss of storage.

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Mechanism Of Action

Amino acids are the basic building blocks of proteins and enzymes and are essential for normal healthy bodily function especially during growth and convalescence. The essential amino acids cannot be made in the body and must be included in the diet or as a supplement.

Vitamins are a class of organic compounds categorized as essential nutrients. They are required by the body in very small quantities.

They are micronutrients that enable the body to use other nutrients. Since the body is unable to synthesize these in sufficient amounts they must be provided by food. A well-balanced diet supplies, in most instances, the vitamin needs of a healthy person. Each vitamin has a specific function to perform and deficiency of any particular vitamin may lead to specific deficiency disease. e.g.:

Vitamin A is essential for night vision and for the integrity of mucosal and epithelial surfaces. The classical effect of deficiency is xerophthalmia, which can lead to keratomalacia and corneal perforation.

Vitamin D plays an active role in mechanisms that control calcium metabolism and its deficiency could lead to inadequate absorption of calcium and phosphate which may result in rickets and osteomalacia.

Vitamins of the B complex group play a part in metabolism of carbohydrate, alcohol and branched chain amino acids. They have a vital role in cellular oxidation and in the synthesis of DNA and fatty acids in myelin. Vitamin C is essential for collagen formulation and tissue repair in the body. It is also involved in the utilization of carbohydrates, synthesis of lipids and proteins and the preservation of blood vessel integrity.

Indications Of Testyfer Syrup

It is used as a supplement in the treatment of conditions associated with deficiency of certain vitamins and amino acids, such as severe infections, degenerative diseases, endocrine dysfunction, surgical procedures, injuries, burns, old age, beriberi, riboflavinosis or pellagra.

Contraindications

It is contra-indicated in patients known to be hypersensitive to any of its components and in patients with hypervitaminosis.

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Dosage Of Testyfer Syrup

Children: (2-6 years) 5ml, 2 to 3 times daily.

(7-14 years) 10ml, 2 to 3 times daily.

Adult: 10ml, 3 times daily or as directed by the Physician.

Precautions

It is not intended for the treatment of severe specific vitamin deficiencies.

Because injudicious use of vitamins may cause toxic reactions, parents should be urged to follow the physician's instructions regarding dosage. Concurrent use of other preparations with vitamins may lead to toxicity and overdose.

Side-effects Of Testyfer Syrup

Water soluble vitamins seldom cause toxicity in people with normal renal function. Hypersensitivity reactions with thiamine are rare and have been reported mostly with parenteral administration. Rare allergic reactions to pyridoxine have been reported. Hepatomegaly, leukopenia and projectile vomiting have been reported as symptoms of vitamin toxicity. Elevated serum calcium and multiple areas of tissue calcification have been reported with hypervitaminosis D.

Drug Interactions

Most diets provide more protein than the body needs, causing excess nitrogen to be excreted as urea in urine. The excess nitrogen has been linked in some studies with reduced kidney function in old age. Most, but not all studies have found that when people have impaired kidney function, restricting dietary intake of protein slows the rate of decline of kidney function.

Excessive protein intake also can increase excretion of calcium and some evidence has linked high-protein diets with osteoporosis, particularly regarding animal protein. On the other hand, some protein is needed for bone formation. A double-blind study showed that elderly people whose diets provided slightly less than the recommended amount of protein suffered less bone loss if they consumed an additional 20 grams of protein per day.

A doctor can help people assess their protein intake. Non-selective monoamine oxidase (MAO) inhibitors: including phenelzine sulfate, tranylcypromine sulfate and pargyline HC1-Concomitant use of L-phenylalanine and non-selective MAO inhibitors may cause hypertension.

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Selegiline: L-phenylalanine and the selective MAO inhibitor selegiline may have synergistic antidepressant activity if used concomitantly.

Neuroleptic Drugs: L-phenylalanine may potentiate the tardive dyskinesia side reactions of neuroleptic drugs if used concomitantly with them.

Acetaminophen and methotrexate: L-methionine may decrease hepatic toxicity in those with acetaminophen overdosage or in those taking methotrexate. Theoretically, it may decrease hepatic toxicity in the case of other potential hepatotoxic drugs, as well.

Gentamicin: Methionine may protect against the ototoxic effects of gentamicin.

Overdosage

Water soluble vitamins seldom cause toxicity in people with normal renal function. Hypervitaminosis A occurs with an intake far in excess of the daily requirement and recommended dosage. The signs and symptoms include dry and pruritic skin, skin desquamations, erythematous dermatitis, disturbed hair growth, fissures of the lips, pain and tenderness of bone, hyperostosis, headache, papilledema, anorexia, oedema, fatigue, irritability, hemorrhage, fibrosis, sclerosis of central veins and cirrhosis.

Intracranial pressure may increase. Raised alkaline phosphatase and hypercalcaemia have been reported.

Hypervitaminosis D is associated with weakness, fatigue, lassitude, headache, nausea, vomiting and diarrhea. Hypercalcaemia which manifests as polyuria, nocturia and proteinuria, nephrolithiasis, diffused nephrocalcinosis. Severe hypercalcaemia may arrest bone growth.