Epiderm Cream/Lotion Composition, Use, Dose, Side Effect

Epiderm is a combination topical medication. It comes in cream and lotion. They are manufactured in India by Shalina Laboratories Pvt Ltd.

Epiderm cream and lotion

Composition Of Epiderm Cream

Each gram contains:

Betamethasone Dipropionate USP 0.643mg, Gentamicin Sulfate BP equivalent to Gentamicin base 1mg, Tolnaftate USP 10mg, iodochlorhydroxyquinoline 10mg, Chlorocresol BP (Preservative) 1mg.

Excipients for Cream: Cetomacrogol-1000 BP, Cetostearyl alcohol BP, White soft Paraffin BP, Purified water B, Propylene Glycol BP and Disodium Hydrogen Phosphate dihydrate BP.

Composition Of Epiderm Lotion

Each ml contains:

Betamethasone Dipropionate USP 0.643mg, Gentamicin Sulfate BP equivalent to Gentamicin base 1mg, Tolnaftate USP 10 mg, iodochlorhydroxyquinoline 10mg, Chlorocresol BP (Preservative) 1mg.

Excipients for Lotion: Cetomacrogol-1000 BP, Cetostearyl alcohol BP, White soft Paraffin BP, Purified water BP, Paraffin liquid heavy BP. Propylene Glycol BP and Disodium Hydrogen Phosphate dihydrate BP.

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Pharmacological Category

Epiderm Cream/Lotion is a combination of antifungal, anti-bacterial and anti-inflammatory drugs which provide synergetic action in treatment of mixed bacterial and fungal infections.

Pharmacological Action

Corticosteroids are thought to act by the induction of phospholipase A2 inhibitory proteins, collectively called lipocortins. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes. Gentamicin is an aminoglycoside that binds to 30s and 50s ribosomal subunits of susceptible bacteria disrupting protein synthesis, thus rendering the bacterial cell membrane defective. Tolnaftate is an antifungal which inhibits growth of dermatophytes. Iodochlorhydroxyquinoline has antibacterial and antifungal activity.

Therapeutic Indications Of Epiderm Cream/Lotion

Epiderm Cream/Lotion is indicated for the treatment of following: Mixed bacterial and fungal infections, Tinea Infections of the skin (Ringworm), Otitis externa, Seborrhoeic dermatitis, Contact dermatitis, Eczemas Psoriasis, Athlete's foot, Anal and vulval pruritis.

Contraindications

Epiderm Cream/Lotion is contraindicated in patients who are hypersensitive to any of the components of the drug It is also contraindicated in the treatment of herpes simplex, vaccina or varicella.

Dosage And Method Of Administration Of Epiderm Cream/Lotion

Apply 2-3 times of Epiderm Cream/Lotion a day to the affected area or as directed by the physician.

The cream is used for skin. The lotion is used for both skin and hair scalp. When combining both, the lotion should be used first, washed out and apply the cream for the best result.

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Epiderm Lotion: Shake well before use.

Pharmacokinetics Properties of Epiderm Cream/Lotion

Absorption: Percutaneous absorption.

Elimination: Via urine.

Adverse Reactions

Epiderm Cream/Lotion is generally safe. Prolonged, continuous treatment may cause atrophy skin changes leading to: thinning, loss of elasticity dilatation of superficial blood vessels, telangiectasias and ecchymoses. Systemic absorption of corticosteroid can cause hypothalamic-pituitary-adrenal axis suppression, manifestation of cushing's syndrome, hyperglycemia and glycosuria.

Undesirable Effects

Epiderm Cream/Lotion is generally well tolerated. Some of the rarely reported side effects are burning sensation, itching, irritation, dryness, folliculitis, acneiform eruptions, hypopigmentation, maceration of the skin, secondary infection, skin atrophy etc.

Warnings And Precautions For Use In Special Populations

Pediatric Use: HPA axis suppression, Cushing's syndrome and intracranial hypertension have been reported in pediatric patients receiving topical corticosteroids.

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Usage in Pregnancy And Lactation

Epiderm Cream/Lotion is not safe in pregnancy. Physicians should be consulted before initiating therapy with Epiderm Cream/Lotion for nursing mothers.

Drug Interactions

No interaction has been reported on local applications with Epiderm Cream/Lotion. Avoid using other topical medications.

Symptoms Of Over Dosage And Its Treatment

Excessive prolonged use of topical corticosteroids can suppress pituitary-adrenal functions resulting in secondary adrenal insufficiency which is usually reversible. In such cases appropriate symptomatic treatment is indicated. If HPA axis suppression is noted, an attempt should be made to withdraw the drug, reduce the frequency of application, or to substitute a less potent steroid.