Apetabon Composition, Use, Dose, Side Effect

Apetabon is an appetite stimulant. It has the same color and design with apetamin. Because apetamin cannot challenge the imitation, apetabon is gradually gaining prominence. It is manufactured by Gopaldas visram and company limited in India and marketed in Nigeria by suitelife pharmaceutical ltd.

Composition Of Apetabon

Each 5 ml contains:

Cyproheptadine Hydrochloride equivalent to anhydrous Cyproheptadine Hydrochloride BP 2.00 mg

Lysine Hydrochloride BP 150.0 mg

Thiamine Hydrochloride BP 1.5 mg

Riboflavin BP 0.5 mg

Pyridoxine Hydrochloride BP 1.5 mgW

Apetabon

Nicotinamide BP 10.0 mg

Cyanocobalamin B.P 1.0 mcg

Dexpanthenol BP 10.0 mg

Flavor: Mixed Fruit

Flavored Syrup base q.s.

Appropriate overages of vitamins are added to compensate for loss of storage.

Mechanism Of Action

Vitamins are a class of organic compounds categorized as essential nutrients. They are required by the body in very small quantities. They are micronutrients that enable the body to use other nutrients. Since the body is unable to synthesize these in sufficient amounts they must be provided by food.

Read Also: Food to eat when taking apetamin

A well balanced diet supplies, in most instances, the vitamin needs of a healthy person. Each vitamin has a specific function to perform and deficiency of any particular vitamin may lead to specific deficiency disease. e.g: Vitamin A is essential for night vision and for the integrity of mucosal and epithelial surfaces. The classical effect of deficiency is xerophthalmia, which can lead to eratomalacia and corneal perforation. Vitamin D plays an active role in mechanisms that control calcium metabolism and its deficiency could lead to inadequate absorption of calcium and phosphate which may result in rickets and osteomalacia.

Vitamins of the B complex group play a role in metabolism of carbohydrate, alcohol and branched chain amino acids. They have a vital role in the cellular axtcation and in the synthesis of DNA and fatty acids in myelin.

Indication And Use Of Apetabon

1. As an appetite stimulant for patients with decreased appetite or poor eating habits with resulting underweight, where stimulation of appetite with weight gain is desired

2. As an anti allergic and antipruritic

Contraindication

Apetabon is contra-indicated in patients known to be hypersensitive to any of its components and in patients with hypervitaminosis.

Dosage Of Apetabon

Children (2-6 years) 5ml, 2 to 3 times daily before food.

(7-14 years) 10m, 2 10 3 times daily before food

Adult: 10ml 3 times day before food or as directed by the Physician.

Precautions

Apetabon is not intended for the treatment of severe specific vitamin delicences. Because injurious use of vitamins may cause toxic reactions, parents should be urged to follow the physician's instructions regarding dosage. Concurrent use of other preparations with vitamins may lead to toxicity and overdose. Safety and efficacy in children below the age of two years have not been established. Acute authamatic attack: Cyproheptadine should not be used for the treatment of an acute asthamatic attack

Side Effects Of Apetabon

Water soluble vitamins seldom cause toxicity in persons with normal renal function. Hypersensitivity reactions with thiamine are rare and have been reported mostly with parenteral administration. Rare allergic reactions to pyridoxine have been reported. Hepatomegaly, leukopenia and projectile vomiting have been reported as symptoms of vitamins toxicity. Elevated serum calcium and multiple areas of tissue calcification have been reported with hypervitaminosis D.

Read Also: Difference and similarity between apetabon and apetamin

Overdose

Water soluble vitamins seldom cause toxicity in persons with normal renal function. Hypervitaminosis occurs with an intake far in excess of the daily requirement and recommended dosage. The signs and symptoms include dry and pruritic skin, skin desquamations, erythematous dermatitis, disturbed hair growth, fissures of the lips, pain and names of bone, hyperostosis, headache, papilloedema, anorexia, oedema, fatigue, irritability, hemorrhage, fibrosis, sclerosis of central veins and cirrhosis.

Intracranial pressure may be increased. Raised alkaline phosphatase and hypercalcaemia have been reported. Hypervitaminosis D is associated with weakness, fatigue, lassitude, headache, nausea, vomiting and diarrhea. Hypercalcaemia which manifests as polyuria nocturia and proteinuria, nephrolithiasis, diffused nephrocalcinosis. Severs hypercalcemia may arrest bone growth.