Advantage And Disadvantage Of Granulation

Granulation has got lots of advantages more than disadvantages and that is why it is popular in pharmacy today. Granulation process is an inevitable step in tablet manufacturing as it improves flow property and compressibility of powder mass intended for compression. Granulation prevents segregation of the constituents of the powder mix.

Granules

Granulation is the process in which primary powder particles are made to adhere to form larger, multi-particle entities called granules.

Pharmaceutical granules typically have a size range between 0.2 and 4.0 mm, depending on their subsequent use.

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Advantage Of Granulation

1. To enhance powder flow and powder handling

2. Degrease segregation of the powder components

3. To produce “dust free” formulations

4. Improve compressibility of the material

5. To increase the uniformity of drug distribution in the product

6. To densify the material

7. Optimise dissolution profiles of tablets

8. To improve the appearance of a final product

Read Also: Advantage and disadvantage of dry granulation

Disadvantage Of Granulation

1. It is difficult to formulate active pharmaceutical ingredients (API) which are hygroscopic or deliquescent, amorphous oxygen-sensitive, and volatile

2. The process requires an experienced person

3. It includes several processing steps and takes more time, energy, and space, hence it is a costly technique