Manufacture Of Tablet By Wet Granulation Process
Wet granulation is a process of dry mixing, wet mixing, and particle size enlargement, and is a process of particle attachment (agglomeration). Wet granulation techniques consist of homogeneously mixing the active pharmaceutical ingredient (API) with other powder excipients and wetting them in the presence of a binder or granulating fluid, forming larger agglomerates/granules. The wet granules are dried to remove moisture and then either screened or milled to eliminate oversized agglomerates and to control the particle size distribution. Granules Wet granulation is a complex process with a combination of several critical formulation and process variables greatly affecting the outcome. For example, determination of the granulation endpoint is still considered by many to be a fine art, requiring knowledge gained through years of hands-on experience. The window for liquid addition can be very narrow and over-wetting of powder can lead to the entire batch being completely unusable. Read Al...
