Overview Of Intramuscular (IM) Injection
Intramuscular (IM) injection is the method of installing medications into the depth of the bulk of specifically selected muscles. The medication is deposited deep into the muscle mass, past the dermis and subcutaneous tissue, and into the very deepest layers of the muscle, where the rich blood supply allows for rapid and full absorption bypassing the first-pass metabolism. Bulky muscles have good vascularity. Injected drugs quickly reach the systemic circulation less rapid but generally longer lasting than those obtained from IV administration. Slow drug absorption leading to a sustained-release (SR) effect can be achieved with highly insoluble drugs or formulations that are oleaginous or particulate. Aqueous or oleaginous solutions or reconstitutable powder or colloidal suspensions or emulsions or suspensions of drugs may be administered intramuscularly. Any drugs that are nonirritant and soluble may be given IM during an emergency scenario. Drugs in aqueous solution are absorbed more...
