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Pharmacotherapy/Treatment Of Typhoid Fever

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Typhoid fever is a systemic infection caused by salmonella enterica serotype typhimurium (salmonella typhi). Symptoms are non-specific and clinically non-distinguishable from other febrile illnesses. Some people (3-5 percent) can be carriers without exhibiting any symptoms. Clinical severity varies and severe cases can lead to complications or even death. The disease affects about 11-21 million people worldwide. It is estimated to cause between 128000-161000 typhoid related deaths annually around the world. A similar but less severe disease, paratyphoid fever is caused by paratyphi A, B and uncommonly C. The number of infections in many European countries has dropped significantly. This is as a result of improved hygienic conditions. There is hardly any case of death. However, India, Pakistan and many parts of Africa especially Egypt and Nigeria have a significant burden. Typhoid fever Symptoms 1. Prolong fever (39-40°c) 2. Headache 3. Nausea 4. Vomiting 5. Loss of appetite 6. Constipa...

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