DrugXpert Blog

Artemisinin based combination (ACT) is the most used drug in the fight against malaria in Nigeria. Artemether and lumefantrine combination enjoy the largest market share for treating uncomplicated malaria. ACTs are known to improve cure rate, reduce the chance of relapse (recrudescence and reinfection), reduce the development of resistance and decrease transmission of drug resistant parasites. Read Also :  Dosing of artemether and lumefantrine combination There are so many brands of artemether and lumefantrine combination in Nigeria. They come in different strengths and formulations for different weights and age. It is given with food as a six dose regimen of 20 mg artemether and 120 mg lumefantrine. It is given orally two times day for three days depending on body weight. Persons above 35kg are given 80mg artemether and 480mg lumefantrine combination. The novel combination comes in the strength of 20mg artemether and 120mg lumefantrine. That means persons above 35kg will need four...

Artemether and lumefantrine combination therapy is an antimalarial. It is one of the first line treatment for malaria infection. Dob an artemisinin combination therapy, it is one of the first line therapy for uncomplicated malaria including plasmodium falciparum. The dose is based on age and or body weight. Dosage duration is three days. However, something striking in the dosage interval. Artemether And Lumefantrine dosing interval The first and second dose interval is 8 hours. The third dose is 16 hours from the second dose or 24 hours from the first dose. Afterwards, subsequent doses will be 12 hours interval. Read Also : Dosing frequency of Artemether And Lumefantrine Sometimes, one wonder why the first and second dose have such a short dosage interval and the third have a long dosage interval. This becomes more interesting when we consider the dosing regimen of other drugs. Many drugs are either every 24 hours, 12 hours, 8 hours, 6 hours, 3 hours interval or something...