Arthocare Composition, Use, Dose, Side Effect

Arthocare is a supplement that is used to manage arthritis. It is made by Ocean Healthcare Limited, India. Fidson Healthcare PLC is responsible for the marketing in Nigeria.

Arthocare

Composition Of Arthocare

Each hard gelatin capsule contains:

Chondroitin Sulfate Sodium USP 200 mg

Glucosamine Hydrochloride USP 250 mg

Mechanism Of Action

Glucosamine HCI- Glucosamine is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids. Oral glucosamine is commonly used for the treatments of osteoarthritis. Since glucosamine is a precursor for glycosaminoglycans, and glycosaminoglycans are a major component of joint cartilage, supplemental glucosamine may help to rebuild cartilage and treat arthritis.

Read Also: Treatment of arthritis

It's used as a therapy for osteoarthritis appears safe, but there is conflicting evidence as to its effectiveness with more recent studies showing Limited to no clinical benefit of use. In the United States, glucosamine is not approved by the Food and Drug Administration for medical use in humans.

Since glucosamine is classified as a dietary supplement safety and formulation are solely the responsibility of the manufacturer, evidence of safety and efficacy is not required as long as it is not advertised as a treatment for a medical condition.

Chondroitin Sulfate-The benefits of chondroitin Sulfate in patients with osteoarthritis is likely the result of a number of effects including its anti-inflammatory activity, the stimulation of the synthesis of proteoglycans and hyaluronic acid and the decrease in catabolic activity of chondrocytes inhibiting the synthesis of proteolytic enzymes, nitric oxide and other substances that contribute to the damage of cartilage matrix and cause the death of articular chondrocytes.

Pharmacokinetics

Glucosamine HCI - After oral administration, the total bioavailability of Glucosamine following first pass metabolism was found to be 26%. Intramuscular bioavailability was noted to be approximately 96%. After the initial period of absorption, the drug is distributed by the blood stream and the major sites of distribution were the liver, kidneys and articular cartilage.

Chondroitin Sulfate-Pharmacokinetic studies performed on humans and experimental animals after oral administration of chondroitin Sulfate revealed that it can be absorbed orally. Chondroitin Sulfate shows first-order kinetics up to single doses of 3,000 mg. Multiple doses of 800 mg in patients with osteoarthritis do not alter the kinetics of chondroitin Sulfate.

The bioavailability of chondroitin Sulfate ranges from 15 to 24% of the orally administered dose. More particularly, on the articular tissue, chondroitin Sulfate is not rapidly absorbed in the gastro-intestinal tract and a high content of labeled chondroitin Sulfate is found in the synovial fluid and cartilage.

Indications Of Arthocare

General - Antiarthritic.

Since it stimulates biosynthesis of cartilage and joint substances such as Hyaluronic acids, Arthocare, a complete chondroprotective is an approach of choice in osteoarthritis. It is also indicated for a number of joint related ailments which include; Rheumatoid arthritis, Fractures, Low backache, Ankylosing spondylitis, Arthritis due to sport injury/active lifestyle and Osteosclerosis.

Eyes

For Uveitis, that is an inflammatory disease of the iris and focusing muscle. It is useful also in preventing changes in the vitreous humor (substance within the eye) and thus protecting the retina from release.

Warnings And Precautions

Women who are pregnant, breastfeeding or who plan to become pregnant and children should not take these supplements. Glucosamine is an amino sugar so people who have diabetes should check their blood sugar more often if they take this supplement. If you are taking Chondroitin Sulfate and a blood-thinning medication, have your blood-clotting prothrombin (protein produced in the liver) time checked more often.

This supplement may contain components similar to the blood-thinning drug heparin. This combination could increase the risk of bleeding. If you are allergic to shellfish, talk to your medical doctor before taking Glucosamine.

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Drug Interactions

Glucosamine should not be taken with heart medications or insulin. Those taking diuretics may require higher amounts of Glucosamine on a daily basis.

Side Effects Of Arthocare

High doses of Glucosamine may cause gastric problems, nausea, diarrhea, indigestion, and heart-bum. Glucosamine should be taken with meals to help avoid these problems.

Contraindications

Hypersensitivity and Pregnancy.

Dosage And Administration Of Arthocare

Dosage requirements are usually based on the body weights. The oral route is used. Should be taken with water.

Persons up to 60 kg: 2 caps twice a day after food. Persons above 60 kg: 3 caps twice a day after food

Pregnancy And Lactation

Avoid during pregnancy and Lactation