Evans Piriton Syrup Composition, Dose, Use, Side Effect

Evans Piriton is one of the old brands of medication used for allergies. It is made in Ogun State by Evans Baroque Limited.

Evans piriton syrup 

Composition Of Evans Piriton

Piriton Tablets: Round, biconvex, creamy yellow tablets each containing chlorpheniramine maleate BP 4mg with PIRITON engraved round the perimeter of one side.

Piriton syrup: Light orange yellow liquid. Each teaspoonful (5ml) of Piriton syrup contains Chlorpheniramine maleate BP 2mg.

Indications Of Evans Piriton

Piriton tablets and syrup are indicated for symptomatic control of all allergic conditions responsive to antihistamines, including hay fever, vasomotor rhinitis, urticaria, angioneurotic oedema, food allergy, drug and serum reactions, insect bites.

Dosage And Administration Of Evans Piriton

The doses below are to be taken three to four times daily or as directed by your physician.

Piriton Tablets

Adults: One tablet

Children (6-12 years): Half to one tablet depending on age and weight.

Piriton Syrup

Children (Below 6 years): Half to one teaspoonful (2.5-5ml) depending on age and weight.

(6-12 years): One to two teaspoonfuls (5-10ml).

Adults (above 12 years): Two teaspoonfuls (10ml).

Contra-Indications

Piriton is contra-indicated in patients who are hypertensive to antihistamines and those that have had MAOI (monoamine oxidase inhibitor) therapy within the previous 14 days.

Precautions

Chlorpheniramine may have an additive effect when used concurrently with hypnotics and anxiolytics causing potentiation of drowsiness.

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A similar additive effect will result from concurrent usage of alcohol with Chlorpheniramine.

Monoamine oxidase inhibitor therapy intensifies the anticholinergic effects of Chlorpheniramine. Chlorpheniramine inhibits phenytoin metabolism and can lead to Phenytoin toxicity. The anticholinergic properties of Chlorpheniramine may cause drowsiness, dizziness, blurred vision and psychomotor impairment, which can seriously hamper the patient's ability to drive and use machinery.

Piriton should only be used during pregnancy when clearly needed and when potential benefit outweighs the potential risks to the fetus.

Side-Effects Of Evans Piriton

Sedation varying from slight drowsiness to deep sleep, inability to concentrate, lassitude, blurred vision, gastrointestinal disturbances such as nausea, vomiting and diarrhea may occasionally occur. Urinary retention, headaches; dryness of the mouth, dizziness, palpitation, tachycardia arrhythmias, hypotension, tightness of the chest, abdominal pain, infrequently Occur.

Allergic reactions including exfoliative dermatitis, photosensitivity and skin reactions, urticaria, twitching, muscular weakness and incoordination. Tinnitus, depression, irritability and Nightmares infrequently occur.

Paradoxical excitation in children and confusional psychosis in the elderly can occur. The effects of alcohol may be increased. In common with other drugs having anticholinergic effects, chlorpheniramine should be used with caution in epilepsy, prostatic hypertrophy, glaucoma, hepatic disease thyrotoxicosis, raised intraocular pressure, severe hypertension or cardiovascular disease. Children and the elderly are more likely to experience the neurological anticholinergic effects.

Overdosage

The estimated lethal dose of Piriton is 25-50mg/kg body weight. Symptoms and signs include sedation, paradoxical stimulation of CNS, toxic psychosis, seizures, apnea, anticholinergic effects dystonic reactions and cardiovascular collapse.

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Treatment includes gastric lavage or emesis using Syrup of Ipecacuanha. Following these measures, activated charcoal and cathartics may be administered to minimize absorption. If overdosage is by the oral route, other symptomatic and supportive measures should be provided with special attention to cardiac, respiratory, renal and hepatic functions and fluid and electrolyte balance.

Treat hypotension and arrhythmias vigorously. CNS convulsions may be treated with IV diazepam or phenytoin. Hemoperfusion may be used in severe cases.