Solotone Composition, Dose, Use, Side Effect

Solotone is a multivitamin. It is manufactured by sagar vitaceuticals NIG LTD and marketed by elbe pharma Nigeria limited.

Solotone capsule

Composition Of Solotone Capsule 

Each sugar-coated tablet contains:

Vitamin A (acetate BP) 2000 IU

Vitamin B1 BP 1 mg

Vitamin B2 BP 1 mg

Vitamin B6 BP 1.34 mg

Vitamin B12 BP 1 mcg

Vitamin D3 BP 200 IU

Selenium (Selenious acid USP) 50 mcg

Phosphorus (as calcium hydrogen phosphate BP) 75 mg

Magnesium (as magnesium sulfate heptahydrate BP) 1 mg

Potassium (as potassium sulfate BP) 1 mg

Appropriate overages of Vitamins are added to compensate for loss on storage.

Pharmacological Properties

Vitamin B1 (thiamine), B2 (riboflavin), B6 (pyridoxine) B12, (cyanocobalamin) are water soluble vitamins which have a major role in maintaining the vital functions of the body.

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Vitamin B is an essential nutrient, the body uses it to process carbohydrates, fat, and proteins.

Riboflavin also plays an important role in certain metabolic reactions. Vitamins Bs principally in the form of the coenzyme pyridoxal 5-phosphate, is involved in a wide range of biochemical reaction, including the metabolism of amino acids and glycogen, the synthesis of nucleic acids, hemoglobin, synthesis of neurotransmitters-serotonin, dopamine, GABA etc. Vitamins B" maintains nerve cells and aids in the production of DNA and RNA and also a necessary nutrient required for formation Of RBCs.

Vitamin A is a fat-soluble vitamin necessary for maintaining poor vision and proper immune system function, growth, bone formation, reproduction, and wound healing.

Vitamin Ds (cholecalciferol) helps the body to maintain the levels of calcium and phosphorus and is therefore essential for building and maintaining healthy bones.

Selenium is a potent antioxidant and an integral part of the body's natural antioxidant glutathione Peroxidase system. It is an effective detoxifier of heavy metals. Its antioxidant properties protect against environmental and chemical sensitivities, and its immune functions enhance the body's antibacterial and antiviral defense.

Magnesium is an essential mineral involved in various metabolic reactions, it is necessary for major biological processes, including the production of cellular energy and the synthesis of nucleic acids and proteins. It is also important for the electrical stability of cells and maintenance of membrane integrity.

Potassium is an essential micromineral with a wide range of biochemical and physiological roles.

It is important in the transmission of nerve impulses, the contraction of cardiac, skeletal and smooth muscle, the production of energy, the synthesis of nucleic acids, the maintenance at intracellular tonicity and the maintenance of normal Mood pressure, muscle contraction, nerve conduction and the regulation of vascular tone among other things.

Phosphorus contributes to energy production by participating in the breakdown of carbohydrates, protein, and fat. It is needed for the growth, maintenance, and repair of all tissues and cells, and for the production of DNA and RNA. Phosphorus is also needed to balance and metabolize other vitamins and minerals, such as vitamin D3 calcium, iodine, magnesium, and zinc.

Indications And Usage Of Solotone Capsule

Solotone is indicated for the prevention of vitamin deficiency, it is also indicated to replenish vitamins post infection, post antibiotic therapy, sometimes it is indicated for use in growing children as a nutritional supplement.

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Contraindications

Known hypersensitivity to any of the vitamins in this product or a pre-existing hypervitaminosis.

This formulation is contraindicated prior to mood sampling for detection of megaloblastic anemia, as the cyanocobalamin can mask serum deficits. Magnesium and potassium supplements should not be used in people with kidney disease or severe heart disease except under physician supervision.

Warnings And Precautions

Pregnant women should not take vitamin A supplements. Use of vitamins B" in diabetic patients may affect blood glucose levels. It also affects the actions of anticonvulsant medications. So epileptics should take it only under skilled supervision. Phosphate in larger doses can lead to diarrhea and calcification (hardening) of organs and soft tissue, and can interfere with the body's ability to use iron, calcium, magnesium, and zinc. Calcium and phosphorus consumption should be balanced.

Drug Interactions

Thiamine, riboflavin and pyridoxine, have been reported to decrease the antibiotic activity at erythromycin, Kanamycin, streptomycin, doxycycline. And lincomycin bleomycin is inactivated in vitro by riboflavin.

Vitamin B either alone or in combination with other B vitamins should be taken at different times from tetracycline because it interferes with its absorption and effectiveness.

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Vitamin A can interact with antacids, anticoagulants, alcohol etc.

Vitamin D supplements should be used cautiously with estrogen. Calcium channel blockers, antacids etc., due to interaction with these drugs. Selenium may reduce toxic side effects associated with cisplatin and doxorubicin; two forms of chemotherapy used to treat cancer.

Pyridoxine may decrease the efficacy of levodopa by increasing its metabolism.

Dosage And Administration Of Solotone 

One tablet per day or as directed by the physician

Overdose

Some people who take high doses of vitamin Bs over a long period of time may experience symptoms such as tingling numbness or weakness in the extremities due to nerve damage. But studies indicate that doses smaller than 500mcg per day appear to be safe. High doses of selenium (>1,000 mcg a day) overtime may produce fatigue, arthritis, hair or fingernail loss, garlicky breath or body odor, gastrointestinal disorders, or irritability.

Toxic levels can result from the abuse of magnesium-containing laxatives. The early signs of toxicity are nausea, vomiting and flushing. Even small doses of magnesium can cause diarrhea in some people. Vitamin A in doses of 25,000-50,0001 U daily for several months can be toxic for people with liver problems, for those taking certain drugs, or for heavy drinkers.