Testymin Syrup Composition, Dose, Use, Side Effect

Testymin Syrup is a multivitamin liquid preparation without iron. It is similar to astymin syrup. It is a product of Gopaldas Visram and Company Limited, India and marketed by Suitelife Pharmaceutical Ltd., Nigeria.

Testymin syrup

Composition Testymin Syrup

Each 15 ml Contains:

Vitamin A BP 2500 IU (As Synthetic Retinol Conc. [oily form])

Vitamin D3 (As Colecalciferol) BP 200 IU

L-Leucine USP 18.3 mg

L-Isoleucine USP 5.9 mg

L-Phenylalanine USP 5 mg

L-Threonine USP 4.2 mg

L-Methionine USP 9.2 mg

L-Tryptophan USP 5 mg

L-Valine USP 6.7 mg

Vitamin B1 (As Thiamine Hydrochloride) BP 5 mg

Vitamin B2 BP 3 mg (As Riboflavin Sodium Phosphate)

Vitamin B6 (Pyridoxine Hydrochloride) BP 1.5 mg

Nicotinamide BP 25 mg

Calcium Pantothenate BP 5 mg

Vitamin B12 (As Cyanocobalamin) BP 2.5 mcg

Folic Acid BP 0.75 mg

Vitamin C (As Ascorbic Acid) BP 40 mg

L-Lysine Hydrochloride USP 25 mg

Vitamin E (As Alpha Tocopheryl Acetate) BP 7.5 IU

Color Caramel USP/NF

Flavored Syrupy Base q.s.

Overages of vitamins added to compensate loss on storage

Mechanism Of Action

Amino acids are the basic building blocks of proteins and enzymes and are essential for normal healthy bodily function especially during growth and convalescence. The essential amino acids cannot be made in the body and must be included in the diet or as a supplement.

Vitamins are a class of organic compounds categorized as essential nutrients. They are required by the body in very small quantities. They are micronutrients that enable the body to use other nutrients. Since the body is unable to synthesize these in sufficient amounts they must be provided by food.

A well balanced diet supplies, in most instances, the vitamin needs of a healthy person. Each vitamin has a specific function to perform and deficiency of any particular vitamin may lead to specific deficiency disease. e.g:

Vitamin A is essential for night vision and for the integrity of mucosal and epithelial surfaces. The classical effect of deficiency is xerophthalmia, which can lead to keratomalacia and corneal perforation.

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Vitamin D plays an active role in mechanisms that control calcium metabolism and its deficiency could lead to inadequate absorption of calcium and phosphate which may result in rickets and osteomalacia.

Vitamins of the B complex group play a part in metabolism of carbohydrate, alcohol and branched chain amino acids. They have a vital role in cellular oxidation and in the synthesis of DNA and fatty acids in myelin.

Vitamin C is essential for collagen formulation and tissue repair in the body. It is also involved in the utilization of carbohydrates, synthesis of lipids and proteins and the preservation of blood vessel integrity.

Indications Of Testymin Syrup

It is used as a supplement in the treatment of conditions associated with deficiency of certain vitamins and amino acids, such as severe infections, degenerative diseases, endocrine dysfunction, surgical procedures, injuries, burns, old age, beri-beri, riboflavinosis or pellagra.

Contraindications

It is contra-indicated in patients known to be hypersensitive to any of its components and in patients with hypervitaminosis.

Dosage Of Testymin Syrup

Children: (2-6 years) 5ml, 2 to 3 times daily.

(7-14 years) 10ml, 2 to 3 times daily.

Adult: 10ml, 3 times daily

or as directed by the Physician.

Precautions

It is not intended for the treatment of severe specific vitamin deficiencies.

Because injudicious use of vitamins may cause toxic reactions, parents should be urged to follow the physician's instructions regarding dosage. Concurrent use of other preparations with vitamins may lead to toxicity and overdose.

Side-effects Of Testymin Syrup

Water soluble vitamins seldom cause toxicity in persons with normal renal function. Hypersensitivity reactions with thiamine are rare and have been reported mostly with parenteral administration. Rare allergic reaction to pyridoxine has been reported. Hepatomegaly, leukopenia and projectile vomiting have been reported as symptoms of vitamins toxicity. Elevated serum calcium and multiple areas of tissue calcification has been reported with hypervitaminosis D.

Drug Interactions

Most diets provide more protein than the body needs, causing excess nitrogen to be excreted as urea in urine. The excess nitrogen has been linked in some studies with reduced kidney function in old age. Most, but not all studies have found that when people have impaired kidney function, restricting dietary intake of protein slows the rate of decline of kidney function.

Excessive protein intake also can increase excretion of calcium and some evidence has linked high-protein diets with osteoporosis, particularly regarding animal protein. On the other hand, some protein is needed for bone formation. A double-blind study showed that elderly people whose diets provided slightly less than the recommended amount of protein suffered less bone loss if they consumed an additional 20 grams of protein per day. A doctor can help people assess their protein intake.

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Non-selective monoamine oxidase (MAO) inhibitors including phenelzine sulfate, tranylcypromine sulfate and pargyline HC1: Concomitant use of L-phenylalanine and non-selective MAO inhibitors may cause hypertension.

Selegiline: L-phenylalanine and the selective MAO inhibitor selegiline may have synergistic antidepressant activity if used concomitantly.

Neuroleptic Drugs: L-phenylalanine may potentiate the tardive dyskinesia side reactions of neuroleptic drugs if used concomitantly with them.

Acetaminophen and methotrexate: L-methionine may decrease hepatic toxicity in those with acetaminophen overdosage or in those taking methotrexate. Theoretically, it may decrease hepatic toxicity in the case of other potential hepatotoxic drugs, as well.

Gentamicin: Methionine may protect against the ototoxic effects of gentamicin.

Overdosage

Water soluble vitamins seldom cause toxicity in persons with normal renal function. Hypervitaminosis A occurs with an intake far in excess of the daily requirement and recommended dosage. The signs and symptoms include dry and pruritic skin, skin desquamations, erythematous dermatitis, disturbed hair growth, fissures of the lips, pain and tenderness of bone, hyperostosis, headache, papilledema, anorexia, oedema, fatigue, irritability, hemorrhage, fibrosis, sclerosis of central veins and cirrhosis.

Intracranial pressure may be increased. Raised alkaline phosphatase and hypercalcaemia have been reported.

Hypervitaminosis D is associated with weakness, fatigue, lassitude, headache, nausea, vomiting and diarrhea. Hypercalcaemia which manifests as polyuria, nocturia and proteinuria, nephrolithiasis, diffused nephrocalcinosis. Severe hypercalcaemia may arrest bone growth.