Shaltoux Expectorant Composition, Use, Dose, Side effect
Shaltoux expectorant is cough syrup. It is also called Shaltoux chesty cough. It is used to relieve cough and sore throat symptoms. It is manufactured in India by Shalina Laboratories Pvt Ltd.
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| Shaltoux expectorant |
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| Shaltoux chesty cough |
Identification
Shaltoux is an effective expectorant which gives prompt and dependable relief in various broncho-pulmonary disorders. As a mucolytic agent, it also facilitates expulsion of accumulated sputum by reducing its viscosity and stickiness.
Composition Of Shaltoux Expectorant
Each 10ml of shaltoux expectorant contains:
Salbutamol Sulfate BP equivalent to salbutamol 2mg
Bromhexine Hydrochloride BP 4mg
Guaifenesin USP 100mg
Menthol BP 1mg
Excipients: Sucrose, Sorbitol Solution BP, Propylene Glycol BP, Sodium Benzoate BP, Hydrochloric Acid BP.
Color: Sunset Yellow, Flavor Mixed fruit and Purified Water BP
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Pharmacological Action
Salbutamol is a beta-adrenergic drug, which stimulates adenyl cyclase, the enzyme which catalyzes the formation of cyclic-3,5'-adenosine monophosphate (cyclic AMP) from adenosine triphosphate (ATP) in beta adrenergic cells. The cyclic AMP thus mediates the cellular responses. Increased cyclic AMP levels are associated with relaxation of bronchial smooth muscle and inhibition of release of mediators of immediate hypersensitivity from cells, especially from mast cells.
Bromhexine is a mucolytic agent. It renders the sputum less viscous and less sticky and thereby facilitates its easy expulsion from the respiratory tract. Bromhexine is rapidly absorbed from the gastrointestinal tract. Bromhexine produces a rarefaction and fragmentation of mucopolysaccharide fibers in the sputum. By this action, it reduces the viscosity of the sputum and hence is considered the drug of choice in conditions associated with productive cough.
Guaifenesin acts by stimulating receptors in the gastric mucosa that initiates a reflex secretion of respiratory tract fluid, thereby increasing the volume and decreasing the viscosity of bronchial secretions. Studies with guaifenesin indicate that it is rapidly absorbed from the gastrointestinal tract. Menthol gives soothing relief to the irritated and inflamed respiratory mucosa.
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Pharmacokinetics
Indication Of Shaltoux Expectorant
Shaltoux is indicated in the treatment of the following disorders: Bronchial Asthma, Emphysema, Acute and chronic Bronchitis, Other bronchospastic conditions associated with mucous secretion. Symptomatic relief of imitating non-productive cough associated with upper and lower respiratory tract congestion.
Contra-indication
Shaltoux is contraindicated:
i) in patients having hypersensitivity to any of its components.
ii) in the presence of an intracranial lesion associated with increased intracranial pressure and whenever ventilatory function is depressed.
iii) in patients having hypertension, hyperthyroidism, serious cardiovascular disorders, peptic ulcers and in those who are diabetic.
Dosage And Directions For Use Of Shaltoux Expectorant
Adults and pediatric patients over 12 years of age: The usual starting dosage for adults and children over 12 years of age is 1 tablespoon three times a day. If a favorable response does not occur, the dose can be increased on the advice of the medical doctor.
Pediatric patients to 12 years of age: The usual starting dosage for children to 12 years of age is 1 teaspoonful three times a day. If a favorable response does not occur, the dose can be increased on the advice of the medical doctor.
Pediatric patients 2 to 6 years of age: Dosing in children 2 to 6 years of age should be initiated at 0.1 mg/kg of body weight three times a day. The starting dosage should not exceed 1 teaspoonful three times a day. If a favorable response does not occur, the dose can be increased on the advice of the medical doctor.
Pediatric patients under 2 years of age: Consult medical doctor
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Side Effect Of Shaltoux Expectorant
Shaltoux is generally well tolerated. Some of the rarely reported side effects are nervousness, shakiness, tremor, headache, dizziness, excitement, sleeplessness, dilated pupils, weakness, nausea, unusual taste, vertigo, and vomiting. These side effects are generally transient in nature, and it is usually not necessary to discontinue treatment. In selected cases, however, dosage may be reduced temporarily after the reaction has subsided. Dosage should be increased in small increments to the optimal dosage.
Adverse Reaction
Frequent and prolonged use of Shaltoux may result in adverse effects like palpitations, chest pain, rapid heart rate, tremor, or nervousness.
Use In Pregnancy
Shaltoux should be used with caution in pregnancy, only if clearly needed.
Use In Nursing Mothers
Shaltoux should be used with caution in the case of nursing mothers only if clearly needed.
Drugs Interactions
Beclomethasone or theophylline: Enhances respiratory function.
Beta-blockers: Inhibits the bronchodilator effect of sympathomimetic bronchodilator
Monoamine oxidase inhibitor (MAD), methyldopa, ergonovine: Increased vasopressor response Lithium: Decreased vasopressor response.
Other sympathomimetic: Increases the effect of drugs.
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