Polygel Suspension And Tablet Composition, Use, Dose, Side Effect
Polygel is an antacid. It comes in suspension and tablet. It is used to relieve symptoms of ulcer and related conditions. Polygel is manufactured in India by Shalina Laboratories Pvt Ltd.
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| Polygel suspension and tablet |
Composition Of Polygel Suspension And Tablet
Polygel Suspension
Each 5ml contains:
Simethicone USP 50mg
Magnesium Hydroxide USP 250 mg
Dried Aluminum Hydroxide gel USP 250mg
Color: Erythrosine and Tartrazine
Flavor: Mint.
Excipients: Sodium Methyl Hydroxybenzoate BP, Sodium Propyl Hydroxybenzoate BP, Saccharin Sodium BP, Sodium Citrate BP, Carmellose Sodium BP, Purified Water BP, Sorbitol Solution BP, Polysorbate 80 BP, Bronopol BP, Levomenthol (Menthol) BP, Peppermint Oil BP, Magnesium Aluminum Silicate Type IC (Veegum HV) and Sodium Hypochlorite solution (dilute) (4%) BP.
Read Also: Best antacid for ulcer
Polygel Tablets
Each chewable tablet contains:
Dried Aluminum Hydroxide Gel BP 300mg
Magnesium Aluminum Silicate Hydrate BP 50mg
Magnesium Hydroxide BP 25mg
Simethicone BP 25mg
Color: Erythrosine Supra
Flavor: Peppermint Oil
Excipients: Sucrose BP, Mannitol BP. Povidone BP. Methyl Hydroxybenzoate BP, Propyl Hydroxybenzoate BP, Saccharin Sodium BP, Purified Talc BP, Magnesium Stearate BP.
Pharmacological Category
Polygel is a well-balanced, pleasant-lasting. antacid/anti-gas medication that provides consistent, effective relief of symptoms associated with gastric hyperacidity and excess gas. Polygel contains two proven antacids, aluminum hydroxide gel and magnesium hydroxide/magnesium aluminum silicate hydrate plus dimethicone/simethicone for gas relief.
Pharmacological Action
Activated Dimethicone: Simethicone is an antifoaming agent to reduce flatulence. It is a silicon polymer that lowers surface tension and allows the small bubbles of froth to coalesce into large bubbles that can be more easily passed up from the stomach or down from the colon. It is chemically inert and has no known systemic action.
Aluminum hydroxide is used primarily as antacid. Main clinical use of aluminum hydroxide is as an agent for neutralizing gastric acid. Aluminum hydroxide acts as an adsorbent of pepsin at a pH above 3. Aluminum hydroxide salts delay gastric emptying and relax gastrointestinal smooth muscle. This contributes to the constipating effect of Aluminium hydroxide. It also helps to promote a mucosal barrier to acid by stimulating mucus secretion. It interferes with phosphate absorption by forming insoluble aluminum phosphate in the gut lumen. It also inhibits the absorption of fluoride ions and binds to some fatty acids and proteins in the gut. Aluminum hydroxide appears to bind to bile acids with an affinity close to that seen with cholestyramine.
Magnesium Hydroxide/Magnesium Aluminum Silicate Hydrate has laxative action and is often given with Aluminum Hydroxide gel which has a constipating action. Because of its insolubility, the antacid effect is usually prolonged over several hours. Magnesium hydroxide increases intestinal motility. Thus, Polygel contains the right balance of aluminum and magnesium compounds so as to significantly change bowel function.
Therapeutic Indications Of Polygel Suspension And Tablet
Polygel is indicated for the relief of acid indigestion, heartburn, sour stomach and symptoms of gas and stomach upset associated with those conditions. It is also indicated for the symptomatic relief of hyperacidity associated with the diagnosis of peptic ulcer, gastritis, peptic oesophagitis and hiatal hemia and as antiflatulent to alleviate the symptoms of mucus-entrapped gas including postoperative gas pain.
Contraindication
Polygel is not suitable in those patients who have shown prior history of hypersensitivity to any of the components of the drug. It is also contraindicated in patients with renal failure.
Dosage And Method Of Administration Polygel Suspension And Tablet
Polygel Suspension
Instruction: Shake well before use.
Adults and children over 12 years: 2-4 teaspoonfuls (10m) to 20ml), 4 times a day or as directed by the physician. Higher doses are required for the treatment of peptic ulcer.
Children: 5-12 years. Half the adult dose.
Read Also: Why antacids are taken after food
Polygel Tablets:
Adults and children over 12 years: 1-2 tablets, ½ to 1 hour after the meal and at bedtime or as directed by the physician. Higher doses are required for the treatment of peptic ulcer.
Child 5-12 years: Half the adult dose.
Pharmacokinetics Properties
Adverse Reactions
The adverse effects that may be encountered with Polygel are changes in bowel function, diarrhea being the common symptom. A small reduction in dosage may often alleviate these symptoms.
Undesirable Effects
Polygel is a well-tolerated antacid. Constipation or stomach cramps, loss of appetite, vomiting, dizziness and headache may occur very rarely.
Warnings And Precautions For Use In Special Populations
Aluminum may cause nausea, vomiting and constipation. Large doses can cause intestinal obstruction. Excessive or normal doses in patients with low phosphate diets may cause phosphate depletion accompanied by increased resorption and urinary excretion of calcium with the risk of osteomalacia. Osteomalacia, with chronic renal failure on high aluminum dose as a phosphate binding agent.
Magnesium may cause diarrhea. Hypomagnesaemia may occur if renal function is impaired. Magnesium hydroxide and other magnesium salts, in the presence of renal insufficiency, may cause central nervous system depression.
Aluminum and magnesium may alter the absorption of other medicines from the gastro-intestinal tract administered concomitantly.
Usage in Pregnancy And Lactation
Polygel is safe in pregnancy.
Read Also: Main causes of ulcer
Use In Nursing Mothers
Caution should be exercised when Polygel is administered to nursing mothers.
Effects On Ability To Drive And Operate Machinery
Not applicable.
Drug Interactions
Fluaroquinolone: Polygel may reduce the potency of this drug.
Isoniazid (oral): Polygel may reduce effects of isoniazid.
Ketoconazole, methenamine: Polygel may decrease the effects of ketoconazole or methenamine.
Mecamylamine: Polygel may potentiate the effects of mecamylamine.
Sodium polystyrene sulfonate resin (SPSR): Polygel may decrease the effectiveness of antacids.
Tetracyclines: Polygel may decrease the effects of both drugs; Polygel should not be taken within 3 to 4 hours of tetracycline.
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