Novogold Forte Composition, Dose, Use, Side Effect

Novogold forte is a drug containing cyproheptadine and vitamins. It is an appetite stimulant and also doubles as a supplement. It is made by Mancare Pharmaceuticals PVT. LTD. for NCI Pharma Chem Ind. Ltd., Lagos State, Nigeria.

Novogold forte

Composition Of Novogold Forte

Each coated tablet contains:

Cyproheptadine Hydrochloride (anhydrous) BP (2.0 mg)

- Vitamin A (as acetate) BP (1600 IU)

- Vitamin D3 BP (200 IU)

- Thiamine Hydrochloride BP (2.0 mg)

- Riboflavin BP (2.0 mg)

- Cyanocobalamin BP (1.0 mcg)

- Nicotinamide BP (15 mg)

- Calcium Pantothenate BP (5.0 mg)

Indications Of Novogold Forte

Cyproheptadine with multivitamin tablets is indicated in symptomatic relief of hypersensitivity reactions including urticaria, angioedema rhinitis, and conjunctivitis, and in pruritic skin disorders. It has an antimuscarinic and central sedative actively. It is used in prophylaxis and treatment of vascular and migraine headaches. It is indicated for the control of diarrhea associated with the carcinoid syndrome.

Uses

Cyproheptadine with multivitamin tablets is a histamine II I-receptor and serotonin antagonist. As such it is used for the symptomatic relief of hypersensitivity reactions as well as in pruritic skin disorders. Other uses are relief of migraine.

Vitamin B1 is an essential coenzyme for carbohydrate metabolism. Vitamin B2 is essential for utilization of energy from food. Niacinamide is involved in electron transfer reactions in the respiratory chain.

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Vitamin D supplementation should be used with caution in those with hypercalcemia 1a or conditions that may lead to hypercalcemia such as hyperparathyroidism and those who-form calcium-containing kidney stones. High doses of vitamin D can lead to elevated levels of calcium that reside in the blood and soft tissues. Bone pain, high blood pressure, formation of kidney stones, renal failure, and increased risk of heart disease can occur.

Vitamin A, and more specifically, retinoic acid, appears to maintain normal skin health by switching on genes and differentiating keratinocyte mature skin cells into mature epidermal cells. It is important for growth and development, for the maintenance of the immune system and good vision. Vitamin B12 or cyanocobalamin, is a vitamin the body needs for important functions such as making DNA cells and forming red blood cells. Animal products, such as meat, milk and eggs are rich in vitamin B12. Most individuals get enough vitamin B12 with a balanced diet.

Adverse Effects (Side Effects) Of Antihistamines (Novogold Forte)

Histamine H1 receptor antagonists possess antimuscarinic properties: dry mouth, thickened respiratory tract, secretions and tightness of the chest, blurred vision, urinary difficulty, reduction in tone and motility of gastrointestinal tract resulting in constipation and increased gastric reflux: in high doses transient bradycardia followed by tachycardia with palpitations and arrhythmias.

Blood disorders: rare blood disorders have been reported. These include agranulocytosis, i.e. eucapnia, hemolytic anemia, fetal abnormalities. Various antihistamines have been associated with fetal abnormalities when taken during pregnancies.

Overdose

Overdose may be fatal especially in infants and children. CNS stimulation predominates over CNS depression causing ataxia, tremors, excitement, psychoses, hallucinations and convulsions. In adults, CNS depression is more common with drowsiness, coma and convulsions progressing to respiratory failure or possibly cardiovascular collapse.

Treatment Of Adverse Effects Of Hi-receptor Antagonist

 Antihistamine

1. The stomach should immediately be emptied.

2. Emetics may be administered if the patient is conscious.

3. Activated charcoal has been given.

4. Convulsions may be controlled with diazepam although CNS depressants need to be avoided.

5. Supportive and symptomatic treatment may include artificial respiration, external cooling for hyperpyrexia, and intravenous fluids. Vasopressors such as noradrenaline or phenylephrine may be used, but adrenaline must not be used.

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Precautions And warnings

1. Antihistamines should not be given to premature infants or neonates: since they have increased susceptibility to antimuscarinic effects.

2. Elderly patients are also more susceptible.

3. Patients on antihistamine treatment should not drive or operate machinery. They should avoid alcoholic drinks.

4. Antihistamines should be used with precaution in closed angle glaucoma, urinary retention, prostatic hypertrophy, or pyloroduodenal obstruction.

5. Patients with epilepsy, severe cardiovascular disorders, liver disorders should use an antihistamine with caution

6. Patients with asthma need to be cautious.

7. Pro and con studies to the use of antihistamines during pregnancy have been published.

Interactions Of Antihistamines

1. Antihistamines may enhance the sedative effects of CNS depressants; alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives and neuroleptics.

2. Monoamine oxidase (MAO) inhibitors may enhance the antimuscarinic effects of antihistamines; the latter have an additive antimuscarinic action with other antimuscarinic drugs like atropine and non-cyclic antidepressants.

3. Antihistamines may suppress positive skin test results and should stop several clays before the test.

Vitamin Administration Adverse Effects/precautions To Be Taken

Adverse effects due to Vitamin in Novogold Forte are practically non-existent.

1 Hypersensitivity reactions have occurred with Thiamine mainly after parenteral administration.

2. Riboflavin has no adverse effects.

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3. A possible reaction to a cyanocobalamin injection is swelling. The swelling may occur in the arms, legs, hands, ankles and feet. Check with your medical doctor if any of these most common side effects persist or become bothersome: mild diarrhea; nausea; stomach upset.

Seek medical attention right away if any of these severe side effects occur while taking multivitamin: Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); feeling of swelling of the entire body; numbness or tingling of the skin.

Dosage Of Novogold Forte

As directed by the physician. Follow strictly the medical doctor's prescription, the method of use and the instructions of the pharmacist who dispenses the medicine. Do not repeat the same prescription without consulting a medical doctor.