Day By Day Vitamin C And Glucose Composition, Use, Dose, Side Effect

Day by day vitamin C and glucose are vitamin tablets. It supplies vitamin C and glucose to individuals instantly. It is made by Maxheal pharmaceutical India and marketed by Greenlife pharmaceuticals ltd, Nigeria.

Day by day vitamin C and glucose

Composition Of Day By Day Vitamin C And Glucose

Each Chewable Tablet contains:

Ascorbic Acid BP.............50mg

**Glucose BP. ....150mg

Excipients.......q.s.

Color: Sunset Yellow

**This product contains additional Glucose used as excipient.

Pharmacological Properties

Pharmacokinetic Properties

Ascorbic Acid (Vitamin C)

Absorption And Distribution

Ascorbic acid is readily absorbed by active transport from the intestine. The proportion absorbed decreases with dose.

The plasma half-life of ascorbic acid in humans is 16 days. However, in vitamin C replete patients excess Ascorbate is eliminated rapidly with a half-life of 3.4 hours. Recent kinetic studies have, for instance, identified an increase in dietary Ascorbate requirements in smokers, but have not identified a consistent difference between the two sexes, or different age groups. An increasing proportion of ingested ascorbic acid is excreted when daily intake rises.

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Ascorbic acid and its metabolites are excreted primarily in the urine with 85% of an intravenous dose to vitamin C replete with patients recovered in the urine in 24 hours. Human breast milk contains 40-100 mg ascorbic acid, depending on the mother's intake of the vitamin. Ascorbic acid also crosses the placenta by active transport.

Metabolism

The main route of excretion of ascorbic acid is in urine. There is no evidence of enterohepatic circulation but secretion into the stomach has been shown when the plasma concentration of ascorbic acid is about 15 mg1-1 absorbed doses are excreted largely unchanged in the urine with small amounts as dehydroascorbic acid and diketogulonic acid. Some other degradation products described recently, have not yet been found in vivo.

Vitamin C is readily oxidized to the dehydro form by removal of hydrogen from the enediol group of ascorbic acid. The reaction is part of the hydrogen transfer system. The two forms are interconvertible with a free radical intermediate, known as ascorbate free radical, detected by electron spin resonance assay. Irreversible breakdown yields 2.3- diketogulonic acid, oxalate and other products. Ascorbic acid is involved in many biochemical reactions including the following;

Conversion of proline and lysine residues in collagen to hydroxyproline and hydroxylysine in the course of collagen synthesis (ii) oxidation of lysine side chains in proteins to provide hydroxy trimethyl-lysine for carnitine biosynthesis (iii) a-amidation of certain hormone precursors. Vitamin c status can affect the hepatic oxidation of drugs. Ascorbic acid protects the enzyme p-hydroxyphenyl pyruvic acid oxidase from inhibition by its substrate.

This protection is necessary only after ingestion of large amounts of tyrosine and may not be significant under normal dietary conditions. In this respect, the role of ascorbic acid is not specific, because many analogues of ascorbic acid and even the dye 2,6-dichlorophenolindophenol, which has a similar redox potential, can replace the vitamin. Vitamin C is essential for synthesis of collagen, and hence for maintenance of tissues such as bone and capillary endothelium.

Glucose

Glucose is rapidly absorbed from the gastro-intestinal tract. Peak plasma concentrations of glucose occur about 40 minutes after oral administration of glucose to hypoglycemic patients. It is metabolized via pyruvate or lactic acid to carbon dioxide and water with the release of energy. All body cells are capable of oxidizing glucose and it forms the principal source of energy in cellular metabolism.

Pharmacodynamic Properties

Ascorbic Acid (Vitamin C)

In humans, an exogenous source of ascorbic acid (vitamin c) is required for collagen formation and tissue repair. Ascorbic acid (vitamin C) is reversibly oxidized to dehydroascorbic acid (vitamin C) in the body. These two forms of vitamins are believed to be important in oxidation-reduction reactions. The vitamin is involved in tyrosine metabolism, conversion of folic acid to folinic acid, carbohydrate metabolism, synthesis of lipids and proteins, iron metabolism, resistance to infections, and cellular respiration.

Ascorbic acid (vitamin C) deficiency results in scurvy. Collagenous structures are primarily affected, and lesions develop in bones and blood vessels. Administration of ascorbic acid (vitamin C) completely reverses the symptoms of ascorbic acid (vitamin C) deficiency.

Indications Of Day By Day Vitamin C And Glucose

Enhancing immune response in infectious disease. Treatment of fatigue, during influenza or convalescence. Antioxidant agent: contribution to the risk reduction of cardiovascular disease.

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Contraindications

Renal lithiasis when the dose of vitamin C> 1g/24 hours.

Dosage And Administration Of Day By Day Vitamin C And Glucose

Dissolve slowly in the mouth;

Adults: 10-20 Chewable Tablets Daily

Children: 4-10 Chewable Tablets daily or as directed by the physician.

Drug Interaction

Concomitant administration of aluminum-containing antacids may increase urinary aluminum elimination. Concurrent administration of antacids and ascorbic acid is not recommended, especially in patients with renal insufficiency. Concomitant administration of aspirin and ascorbic acid may interfere with absorption of ascorbic acid.

Renal excretion of salicylate is not affected and does not lead to reduced anti-inflammatory effects of aspirin. Concurrent administration of ascorbic acid with deferoxamine enhances urinary iron excretion. Cases of cardiomyopathy and congestive heart failure have been reported in patients with idiopathic hemochromatosis and thalassemia receiving deferoxamine who were subsequently given ascorbic acid.

Ascorbic acid should be used with caution in these patients and cardiac function monitored. Ascorbic acid may interfere with biochemical determinations of creatinine, uric acid and glucose in samples of blood and urine.

Side Effects Of Day By Day Vitamin C And Glucose

Common side effects:

-Redness and warm feeling of the skin, or flushing

-Headache

-Nausea, vomiting, or diarrhea

-Upset stomach during or after eating

-Feeling faint

Symptoms And Management Of Overdose

Vitamin C is 2,000 mg per day, or anything above this amount could be considered as an overdose.

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Gastrointestinal Problems: If you consume more than 2,000 mg of vitamin C, you may develop severe gastrointestinal irritation and diarrhea. In addition to significant discomfort, extended episodes of diarrhea or vomiting can lead to dehydration, causing extreme thirst, fatigue, low urine output and reduced blood pressure. Diarrhea and vomiting can also cause additional mineral imbalances in the body.

Kidney Stones: High vitamin C intake is associated with an increased risk of oxalate kidney stones -accounting for approximately 80 percent of all kidney stones. Vitamin C is water-soluble; therefore, your body is flushing all the water it can to get rid of the excess vitamin C. Drink plenty of fluids such as water and Pedialyte (or a sugar-salt solution) to rehydrate and to keep flushing the vitamin C.

Use In Pregnancy And lactation

Ascorbic acid in doses greater than 1g should not be administered during pregnancy as the effect of large doses on the fetus is not known. No problems are anticipated with the administration of ascorbic acid tablets during lactation.