Cenox TN Composition, Use, Side Effect, Dose

Cenox TN is a combination of two different classes of antibiotics. Both works synergistically to increase the effect of the other. Cenox TN is made in India by Meidibios laboratories limited and distributed in Nigeria by Elbe pharma Nigeria limited.

Cenox TN

Composition Of Cenox TN

Each film coated tablet contains:

Ciprofloxacin Hydrochloride USP equivalent to Ciprofloxacin 500mg

Tinidazole BP 600mg

Indications Of Cenox TN

Cenox - TN is indicated in infections like digestive, respiratory, gynecological, post-surgical.

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Mechanism Of Action

Ciprofloxacin is bactericidal and acts on Shigella, Salmonella, E. Coli, Vibrio cholerae etc. It acts by inhibiting DNA synthesis.

Tinidazole is a powerful anaerobicide. It is also effective against Giardia and Entamoeba.

Pharmacokinetics

Ciprofloxacin is rapidly absorbed with a Cmax ranging from 1.5 to 2 mg/l with Tmax of approximately 60 to 75 minutes. It is widely distributed in body fluids and tissues and eliminated primarily by the kidneys. The half-life is about 4 hours, ciprofloxacin is excreted in fetal blood and is excreted in breast milk. After oral administration, tinidazole is almost completely absorbed. Cmax is achieved 2 hours after a single intake of 2 g.

Tinidazole is widely distributed and concentration similar to those in plasma has been achieved in bile, breast milk, Cerebrospinal fluid, saliva, and a variety of body tissues; it crosses the placenta readily. Only 12% is reported to be bound to plasma proteins. Unchanged drugs and metabolites are excreted in the urine and, to a lesser extent, in the feces.

Contraindications

Antacids, calcium, iron and zinc reduce the absorption of ciprofloxacin. Concomitant use of cyclosporine may lead to transient increases in serum creatinine. Consumption of alcohol is prohibited.

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Side Effects Of Cenox TN

Nausea, headache, vomiting, fatigue, abdominal pain, dyspepsia, constipation, sometimes diarrhea, metallic taste, hives, redness, rashes.

Special Precautions

It should not be used in children, during pregnancy and lactation. Caution should be exercised in patients with a history of renal disease and epilepsy. Drink plenty of water during treatment. Avoid ingestion of alcohol.

Dosage Of Cenox TN

Adult: 1 tablet two times a day or as directed by the Physician. Duration depends largely on the severity of the infection on medical advice.

Children and adolescents: Not recommended usually.