Types Of Suppository Bases
The release of drug from suppository bases is one of the important factors in the transmucosal absorption of drugs, since the orifice fluid is small in volume and is viscous compared with gastrointestinal (GI) fluid. Generally, the hydrophilic characteristics of base enhance the release of poorly water-soluble drugs from fatty bases because of the lesser interaction of the resultant complex with vehicles. Suppository base Properties Of An Ideal Suppository Base The ideal suppository base should meet the following general specifications: 1. It should release the medicaments readily. 2. It should be compatible with a variety of drugs. 3. It should melt at body temperature or disperse in the body fluids. 4. It should be nontoxic and nonirritating to mucous membranes. 5. It should be stable on storage. 6. It should not bind or otherwise interfere with release or absorption of drug substances. 7. It should be stable if heated above its melting point. 9. It should be molded easily and should...
